The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features

R Ossenkoppele, YAL Pijnenburg, DC Perry… - Brain, 2015 - academic.oup.com
A 'frontal variant of Alzheimer's disease'has been described in patients with predominant
behavioural or dysexecutive deficits caused by Alzheimer's disease pathology. The …

The identification of cognitive subtypes in Alzheimer's disease dementia using latent class analysis

NME Scheltens, F Galindo-Garre… - Journal of Neurology …, 2016 - jnnp.bmj.com
Objective Alzheimer's disease (AD) is a heterogeneous disorder with complex underlying
neuropathology that is still not completely understood. For better understanding of this …

Cognitive subtypes of probable Alzheimer's disease robustly identified in four cohorts

NME Scheltens, BM Tijms, T Koene, F Barkhof… - Alzheimer's & …, 2017 - Elsevier
Abstract Introduction Patients with Alzheimer's disease (AD) show heterogeneity in profile of
cognitive impairment. We aimed to identify cognitive subtypes in four large AD cohorts using …

[HTML][HTML] Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease

NME Scheltens, K van der Weijden, SM Adriaanse… - NeuroImage: Clinical, 2018 - Elsevier
When differential diagnosis of dementia includes both Alzheimer's disease (AD) and the
behavioural variant of frontotemporal dementia (bvFTD), distribution of cerebral glucose …

Prominent non-memory deficits in Alzheimer's disease are associated with faster disease progression

NME Scheltens, BM Tijms… - Journal of …, 2018 - content.iospress.com
Background: Alzheimer's disease (AD) is a heterogeneous disorder. Objective: To
investigate whether cognitive AD subtypes are associated with different rates of disease …

Exploring effects of Souvenaid on cerebral glucose metabolism in Alzheimer's disease

NME Scheltens, CT Briels, M Yaqub… - … Research & Clinical …, 2019 - Wiley Online Library
Introduction Alzheimer's disease (AD) is associated with synapse loss. Souvenaid,
containing the specific nutrient combination Fortasyn Connect, was designed to improve …

[HTML][HTML] Design of the NL-ENIGMA study: Exploring the effect of Souvenaid on cerebral glucose metabolism in early Alzheimer's disease

NME Scheltens, IS Kuyper, R Boellaard… - Alzheimer's & Dementia …, 2016 - Elsevier
Introduction Alzheimer's disease is associated with early synaptic loss. Specific nutrients are
known to be rate limiting for synapse formation. Studies have shown that administering …

[CITATION][C] [O3–06–04]: PROMINENT NON‐MEMORY DEFICITS IN AD ARE ASSOCIATED WITH A FASTER DISEASE PROGRESSION

WM van der Flier, NME Scheltens… - Alzheimer's & …, 2017 - Wiley Online Library
Background There is considerable heterogeneity in clinical manifestation and rate of decline
among patients with Alzheimer's disease (AD). We previously identified two distinct cognitive …

[CITATION][C] P2‐016: EXPLORING THE EFFECT OF SOUVENAID ON CEREBRAL GLUCOSE METABOLISM IN EARLY ALZHEIMER'S DISEASE

CT Briels, NME Scheltens, MM Yaqub… - Alzheimer's & …, 2019 - Wiley Online Library
Background Alzheimer's disease (AD) is associated with synaptic loss. Souvenaid,
containing the specific nutrient combination Fortasyn Connect, was designed to improve …

[CITATION][C] IC‐02‐03: Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease

NME Scheltens, S Adriaanse, PP Oomen… - Alzheimer's & …, 2015 - Wiley Online Library
Background Hypometabolism of the posterior cingulate cortex (PCC) is associated with
Alzheimer's disease (AD). PCC vulnerability, however, could also be present in other …