Background Pre-term birth (PTB) remains the leading cause of infant mortality and morbidity.
Its etiology is multifactorial, with a strong genetic component. Genetic predisposition for the …

We present a complete DNA sequence and metabolic analysis of the dominant oral
bacterium Fusobacterium nucleatum. Although not considered a major dental pathogen on …

Glutathione transferase Pi (GST-pi, GSTP) is known to strongly affect human susceptibility to
several cancers, asthma and neurodegenerative disorders. As with other glutathione …

Horizontal gene transfer (HGT) can radically alter the genomes of microorganisms, providing
the capacity to adapt to new lifestyles, environments, and hosts. However, the extent of HGT …

Abstract The ERGO TM (http://ergo. integratedgenomics. com/ERGO/) genome analysis and
discovery suite is an integration of biological data from genomics, biochemistry, high …

Microbes can defend their host against virulent infections, but direct evidence for the
adaptive origin of microbe-mediated protection is lacking. Using experimental evolution of a …

Abstract The Library of Apicomplexan Metabolic Pathways (LAMP, http://www. llamp. net) is
a web database that provides near complete mapping from genes to the central metabolic …

Background: Breast cancer metastasis is a highly prevalent cause of death for European
females. DNA microarray analysis has established that primary tumors, which remain …

Anthropogenic endocrine disruptors now contaminate all environments globally, with
concomitant deleterious effects across diverse taxa. While most studies on endocrine …

Dietary restriction (DR), limiting nutrient intake from diet without causing malnutrition, delays
the aging process and extends lifespan in multiple organisms. The conserved life-extending …