Amyotrophic lateral sclerosis (ALS; motor neuron disease) is a relentlessly progressive
disorder. After half a century of trials, only one drug with modest disease-modifying potency …

The management of motor neurone disease (MND) has evolved rapidly over the last two
decades. Although still incurable, MND is not untreatable. From an attitude of nihilism …

The evidence base for diagnosis and management of ALS is still weak, and curative therapy
is lacking. Nonetheless, early diagnosis and symptomatic therapy can profoundly influence …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is familial in
10% of cases. We have identified a missense mutation in the gene encoding fused in …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized
pathologically by ubiquitinated TAR DNA binding protein (TDP-43) inclusions. The function …

Background Amyotrophic lateral sclerosis (ALS) is a progressive disease with no effective
treatment. In an initial study, riluzole decreased mortality and slowed muscle-strength …

Groups of patients with idiopathic Parkinson's disease, either medicated or unmedicated,
were compared with matched groups of normal controls on a computerized battery …

Microglial activation is implicated in the pathogenesis of ALS and can be detected in animal
models of the disease that demonstrate increased survival when treated with anti …

Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder
which includes both clinical and neuropathological features of a frontotemporal lobar …

Neuropsychological investigations of amyotrophic lateral sclerosis (ALS) patients have
revealed variable results on specific tests, despite a similar overall cognitive profile of …