Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

Experiments in both vertebrates and invertebrates have illustrated the competitive nature of
growth and led to the idea that competition is a mechanism of regulating organ and tissue …

The biogenesis of ribosomes is a finely regulated multistep process linked to cell
proliferation and growth—processes which require a high rate of protein synthesis. One of …

Fibroblast growth factors (FGF) play a critical role in bone growth and development affecting
both chondrogenesis and osteogenesis. During the process of intramembranous …

In a previous study, we demonstrated that sodium salicylate (NaSal) selectively inhibits
tumor necrosis factor (TNF)-induced activation of the p42 and p44 mitogen-activated protein …

Axl is a tyrosine kinase receptor and although it is expressed in malignancy such as
leukemia, colon cancer, melanoma, endometrial, prostate and thyroid cancers, its role has …

The ARK (AXL, UFO) receptor is a member of a new family of receptor tyrosine kinases
whose extracellular domain contains a combination of fibronectin type III and …

Proteinopathies are a large group of neurodegenerative diseases caused by both genetic
and sporadic mutations in particular genes which can lead to alterations of the protein …

Genetic analyses in Drosophila epithelia have suggested that the phenomenon of “cell
competition” could participate in organ homeostasis. It has been speculated that competition …

The role of heparin or heparan sulfates in the interaction of basic fibroblast growth factor
(bFGF) with its high affinity receptor were investigated using purified extracellular ligand …