Objective Voluntary upper limb movements are an ecologically important yet insufficiently
explored digital‐motor outcome domain for trials in degenerative ataxia. We extended and …

Background and Objective With its relevance for everyday function, upper-limb-coordination
is an insufficiently explored domain for digital-motor-outcomes in ataxia. Leveraging the trial …

Background and Objective Upper-limb function is insufficiently explored as digital-motor
outcome in ataxia. The Archimedes spiral-drawing-task might serve as a meaningful …

Background Q-Motor Speeded Tapping is a well-established quantitative digital motor
assessment able to detect early motor changes in neurodegenerative diseases. In this task …

Background Q-Motor provided reliable quantitative endpoints in TRACK-HD and several
clinical trials. Finger tapping was the most sensitive assessment of disease progression and …

Background Quantitative digital motor assessments such as the Q-Motor Finger Tapping
have been shown to detect progression (TRACK-HD) and drug effects in multiple clinical …

Background Quantitative digital assessments in clinical trials may increase effect sizes while
reducing population sizes, resulting in more accurate and cost effective trials and less …

Background Q-Motor assessments have been used in a number of large multicenter clinical
studies in Huntington's disease and beyond. Q-Motor has proven to be a robust and …

Background Clinical rating scales in clinical trials for Huntington's disease (HD) have shown
limited sensitivity in the premanifest stage of HD and often suffer from inter-and intra-rater …