DARPP-32: an integrator of neurotransmission
P Svenningsson, A Nishi, G Fisone… - Annu. Rev …, 2004 - annualreviews.org
Dopamine-and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However …
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However …
Adenosine and brain function
BB Fredholm, JF Chen, RA Cunha… - Int Rev …, 2005 - books.google.com
A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …
Depression in Parkinson disease—epidemiology, mechanisms and management
D Aarsland, S Påhlhagen, CG Ballard, U Ehrt… - Nature Reviews …, 2012 - nature.com
Depression occurs in around 35% of patients with Parkinson disease (PD) and is often
persistent. Symptoms of depression can be evident in individuals at the time of diagnosis …
persistent. Symptoms of depression can be evident in individuals at the time of diagnosis …
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum
E Valjent, V Pascoli, P Svenningsson… - Proceedings of the …, 2005 - National Acad Sciences
Many drugs of abuse exert their addictive effects by increasing extracellular dopamine in the
nucleus accumbens, where they likely alter the plasticity of corticostriatal glutamatergic …
nucleus accumbens, where they likely alter the plasticity of corticostriatal glutamatergic …
Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States
P Svenningsson, K Chergui, I Rachleff, M Flajolet… - Science, 2006 - science.org
The pathophysiology of depression remains enigmatic, although abnormalities in serotonin
signaling have been implicated. We have found that the serotonin 1B receptor [5 …
signaling have been implicated. We have found that the serotonin 1B receptor [5 …
Distribution, biochemistry and function of striatal adenosine A2A receptors
P Svenningsson, C Le Moine, G Fisone… - Progress in …, 1999 - Elsevier
It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …
Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment
Dementia is one of the most common and important aspects of Parkinson's disease and has
consequences for patients and caregivers, and has health-related costs. Mild cognitive …
consequences for patients and caregivers, and has health-related costs. Mild cognitive …
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
JA Bibb, J Chen, JR Taylor, P Svenningsson, A Nishi… - Nature, 2001 - nature.com
Cocaine enhances dopamine-mediated neurotransmission by blocking dopamine re-uptake
at axon terminals. Most dopamine-containing nerve terminals innervate medium spiny …
at axon terminals. Most dopamine-containing nerve terminals innervate medium spiny …
Vagotomy and Parkinson disease: A Swedish register–based matched-cohort study
Objective: To examine whether vagotomy decreases the risk of Parkinson disease (PD).
Methods: Using data from nationwide Swedish registers, we conducted a matched-cohort …
Methods: Using data from nationwide Swedish registers, we conducted a matched-cohort …
Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity
P Calabresi, P Gubellini, D Centonze… - Journal of …, 2000 - Soc Neuroscience
A complex chain of intracellular signaling events, critically important in motor control, is
activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At …
activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At …