Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Stroke is the largest single cause of
disability in the UK. While tests based upon biomarkers have been around for decades …

The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …

Objective: In many cases where Huntington disease (HD) is suspected, the genetic test for
HD is negative: these are known as HD phenocopies. A repeat expansion in the C9orf72 …

Background Disease-modifying treatments are in development for Huntington's disease;
crucial to their success is to identify a timepoint in a patient's life when there is a measurable …

This paper considers the identification of large directed graphs for resting-state brain
networks based on biophysical models of distributed neuronal activity, that is, effective …

Objective Differentiating idiopathic Parkinson's disease from atypical parkinsonian
syndromes is challenging, especially in the early stages. We assessed whether the Revised …

Background The earliest white matter changes in Huntington's disease are seen before
disease onset in the premanifest stage around the striatum, within the corpus callosum, and …

Huntington's disease can be predicted many years before symptom onset, and thus makes
an ideal model for studying the earliest mechanisms of neurodegeneration. Diffuse patterns …

Dementia in Parkinson's disease affects 50% of patients within 10 years of diagnosis but
there is wide variation in severity and timing. Thus, robust neuroimaging prediction of …