There is increasing evidence that frontotemporal dementia and amyotrophic lateral sclerosis
are part of a disease continuum. Recently, a hexanucleotide repeat expansion in C9orf72 …

With increased frequency, clinical geneticists are asked for genetic advice on the heredity of
dementia in families. Alzheimer's disease is in most cases a complex disease, but may be …

Background: The major genetic risk factor for late onset Alzheimer's disease (AD) is
theAPOE-4 allele. However, APOE-4 homozygosity is not fully penetrant, suggesting co …

Objectives The chromosome 9 open reading frame 72 gene (C9orf72) hexanucleotide
repeat expansion (C9orf72RE) is the most common genetic cause of behavioural variant …

Background Cerebral small vessel disease (lacunar stroke and cerebral white matter
hyperintensities) is caused by vessel abnormalities of unknown aetiology. Retinal vessels …

Background: Right temporal variant frontotemporal dementia (rtvFTD) has been generally
considered as a right sided variant of semantic variant primary progressive aphasia (svPPA) …

Background: Because the behavioral variant of frontotemporal dementia (bvFTD) shows
major clinical overlap with primary psychiatric disorders (PPD) that affect similar …

Follow-up studies on predictive testing for hereditary neurodegenerative diseases mainly
focussed on psychological outcomes. We investigated whether the social and personal life …

Genetic factors are important in all forms of dementia, especially in early onset dementia.
The frequency of major gene defects in dementia has not been investigated in the …

Methods We ascertained all FTD (n= 13) and ALS patients (n= 4) with the I383V variant
(NM_007375. 3: c. 1147A> G, p. Ile383Val) in TARDBP from three university medical centres …