User profiles for "author:R A Barker"

Roger A Barker

University of Cambridge
Verified email at cam.ac.uk
Cited by 66137

Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines

I Litvan, JG Goldman, AI Tröster… - Movement …, 2012 - Wiley Online Library
Mild cognitive impairment is common in nondemented Parkinson's disease (PD) patients
and may be a harbinger of dementia. In view of its importance, the Movement Disorder …

Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease

AA Kehagia, RA Barker, TW Robbins - The Lancet Neurology, 2010 - thelancet.com
Cognitive impairment in patients with Parkinson's disease is gaining increased clinical
significance owing to the relative success of therapeutic approaches to the motor symptoms …

Evolution of cognitive dysfunction in an incident Parkinson's disease cohort

CH Williams-Gray, T Foltynie, CEG Brayne… - Brain, 2007 - academic.oup.com
We have previously performed detailed clinical and neuropsychological assessments in a
community-based cohort of patients with newly diagnosed parkinsonism, and through …

A functional role for adult hippocampal neurogenesis in spatial pattern separation

CD Clelland, M Choi, C Romberg, GD Clemenson Jr… - Science, 2009 - science.org
The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern
separation—the formation of distinct and orthogonal representations of mnemonic …

The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort

CH Williams-Gray, JR Evans, A Goris, T Foltynie… - Brain, 2009 - academic.oup.com
Cognitive abnormalities are common in Parkinson's disease, with important social and
economic implications. Factors influencing their evolution remain unclear but are crucial to …

Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands

R Cools, RA Barker, BJ Sahakian… - Cerebral cortex, 2001 - academic.oup.com
We investigated how dopamine (DA) systems contribute to cognitive performance in the
domain of learning and attentional flexibility by examining effects of withdrawing DA-ergic …

[HTML][HTML] Targeting huntingtin expression in patients with Huntington's disease

SJ Tabrizi, BR Leavitt… - … England Journal of …, 2019 - Mass Medical Soc
Background Huntington's disease is an autosomal-dominant neurodegenerative disease
caused by CAG trinucleotide repeat expansion in HTT, resulting in a mutant huntingtin …

[HTML][HTML] Molecular diversity of midbrain development in mouse, human, and stem cells

G La Manno, D Gyllborg, S Codeluppi, K Nishimura… - Cell, 2016 - Elsevier
Understanding human embryonic ventral midbrain is of major interest for Parkinson's
disease. However, the cell types, their gene expression dynamics, and their relationship to …

The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study

T Foltynie, CEG Brayne, TW Robbins, RA Barker - Brain, 2004 - academic.oup.com
We have used multiple sources to identify a population‐representative cohort of newly
diagnosed patients with parkinsonism and Parkinson's disease in the UK over a 2‐year …

Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry

SJG Lewis, A Dove, TW Robbins… - Journal of …, 2003 - Soc Neuroscience
Studies in patients with Parkinson's disease (PD) suggest that the characteristic motor
symptoms of the disorder are frequently accompanied by impairments in cognition that are …