User profiles for "author:R. C. Baxter"

Robert C. Baxter

University of Sydney
Verified email at sydney.edu.au
Cited by 34651

Cellular actions of the insulin-like growth factor binding proteins

SM Firth, RC Baxter - Endocrine reviews, 2002 - academic.oup.com
In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell
activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may …

Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities

RC Baxter - American Journal of Physiology-Endocrinology …, 2000 - journals.physiology.org
The insulin-like growth factor (IGF)-binding proteins (IGFBPs) are a family of six homologous
proteins with high binding affinity for IGF-I and IGF-II. Information from NMR and …

IGF binding proteins in cancer: mechanistic and clinical insights

RC Baxter - Nature Reviews Cancer, 2014 - nature.com
The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

Binding proteins for the insulin-like growth factors: structure, regulation and function

RC Baxter, JL Martin - Progress in growth factor research, 1989 - Elsevier
Binding proteins for the insulin-like growth factors (IGF-I and IGF-II) are increasingly being
recognized as modulators of IGF actions in both inhibitory and stimulatory ways. At least …

Insulin-like growth factor binding proteins in the human circulation: a review

RC Baxter - Hormone Research in Paediatrics, 1994 - karger.com
The actions and bioavailability of the insulin-like growth factors (IGFs) are regulated by a
family of six IGF binding proteins. IGFBP-3, the major circulating IGFBP, is unique in …

Diagnosis of growth-hormone deficiency in adults

DM Hoffman, AJ O'Sullivan, KKY Ho, RC Baxter - The Lancet, 1994 - Elsevier
There is no consensus as to the most appropriate method of diagnosing growth-hormone
(GH) deficiency in adults. We have evaluated the relative diagnostic merits of measuring …

Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma.

RC Baxter, JL Martin - The Journal of clinical investigation, 1986 - Am Soc Clin Investig
A specific radioimmunoassay has been established for a growth hormone-dependent
insulinlike growth factor (IGF) binding protein (BP) from human plasma. Although the assay …

Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patients …

G Van den Berghe, P Wouters… - The Journal of …, 1999 - academic.oup.com
Protracted critical illness is marked by protein wasting resistant to feeding, by accumulation
of fat stores, and by suppressed pulsatile release of GH and TSH. We previously showed …

[HTML][HTML] Nuclear import of insulin-like growth factor-binding protein-3 and-5 is mediated by the importin β subunit

LJ Schedlich, SL Le Page, SM Firth, LJ Briggs… - Journal of Biological …, 2000 - ASBMB
Although insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 are known to
modulate cell growth by reversibly sequestering extracellular insulin-like growth factors …

Neuroendocrinology of prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues

G Van den Berghe, F De Zegher… - The Journal of …, 1998 - academic.oup.com
The catabolic state of prolonged critical illness is associated with a low activity of the
thyrotropic and the somatotropic axes. The neuroendocrine component in the pathogenesis …