Dyspraxia is an enigma to many people, both professional and lay alike—what is it, how
does it relate to developmental coordination disorder and associated conditions, how …

Background Tonic‐clonic convulsions and convulsive status epilepticus (currently defined
as a tonic‐clonic convulsion lasting at least 30 minutes) are medical emergencies and …

We conducted a literature review of the intensive care unit-acquired weakness syndromes
(critical illness polyneuropathy, critical illness myopathy and critical illness neuromyopathy) …

Background Valproate is widely accepted as a drug of first choice for patients with
generalised onset seizures, and its broad spectrum of efficacy means it is recommended for …

Background Carbamazepine is widely accepted as a drug of first choice for patients with
partial onset seizures. Several newer drugs possess efficacy against these seizure types but …

Background Rectal diazepam and buccal midazolam are used for emergency treatment of
acute febrile and afebrile (epileptic) seizures in children. We aimed to compare the safety …

Objective To evaluate the safety and preliminary pharmacokinetics of a pharmaceutical
formulation of purified cannabidiol (CBD) in children with Dravet syndrome. Methods …

Background Valproate is a first-line treatment for patients with newly diagnosed idiopathic
generalised or difficult to classify epilepsy, but not for women of child-bearing potential …

Background Levetiracetam and zonisamide are licensed as monotherapy for patients with
focal epilepsy, but there is uncertainty as to whether they should be recommended as first …

Background Phenytoin is the recommended second-line intravenous anticonvulsant for
treatment of paediatric convulsive status epilepticus in the UK; however, some evidence …