User profiles for "author:Roisin McMackin"
Roisin McMackinAcademic Unit of Neurology, Trinity College Dublin Verified email at tcd.ie Cited by 312 |
Measuring network disruption in neurodegenerative diseases: new approaches using signal analysis
Advanced neuroimaging has increased understanding of the pathogenesis and spread of
disease, and offered new therapeutic targets. MRI and positron emission tomography have …
disease, and offered new therapeutic targets. MRI and positron emission tomography have …
[HTML][HTML] Neurophysiological markers of network dysfunction in neurodegenerative diseases
There is strong clinical, imaging and pathological evidence that neurodegeneration is
associated with altered brain connectivity. While functional imaging (fMRI) can detect resting …
associated with altered brain connectivity. While functional imaging (fMRI) can detect resting …
Patterned functional network disruption in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting motor function, with additional evidence of extensive nonmotor involvement …
affecting motor function, with additional evidence of extensive nonmotor involvement …
Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a devastating disease characterized primarily by motor
system degeneration, with clinical evidence of cognitive and behavioural change in up to …
system degeneration, with clinical evidence of cognitive and behavioural change in up to …
Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study
Background Amyotrophic lateral sclerosis (ALS) is often associated with cognitive and/or
behavioural impairment. Cognitive reserve (CR) may play a protective role in offsetting …
behavioural impairment. Cognitive reserve (CR) may play a protective role in offsetting …
Biomarkers in amyotrophic lateral sclerosis: current status and future prospects
Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …
development. Categorization based on clinical features alone can help us predict the …
Functional network dynamics revealed by EEG microstates reflect cognitive decline in amyotrophic lateral sclerosis
Recent electroencephalography (EEG) studies have shown that patterns of brain activity can
be used to differentiate amyotrophic lateral sclerosis (ALS) and control groups. These …
be used to differentiate amyotrophic lateral sclerosis (ALS) and control groups. These …
[HTML][HTML] Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis
R McMackin, S Dukic, E Costello, M Pinto-Grau… - Neurobiology of …, 2021 - Elsevier
We aimed to quantitatively characterize progressive brain network disruption in Amyotrophic
Lateral Sclerosis (ALS) during cognition using the mismatch negativity (MMN), an …
Lateral Sclerosis (ALS) during cognition using the mismatch negativity (MMN), an …
[HTML][HTML] Dysfunction of attention switching networks in amyotrophic lateral sclerosis
Objective To localise and characterise changes in cognitive networks in Amyotrophic Lateral
Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms. Rationale …
Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms. Rationale …
[HTML][HTML] Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS
R McMackin, Y Tadjine, A Fasano, M Mitchell… - Clinical …, 2024 - Elsevier
Objective To establish if induced current direction across the motor cortex alters the
sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical …
sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical …