User profiles for "author:Roisin McMackin"

Roisin McMackin

Academic Unit of Neurology, Trinity College Dublin
Verified email at tcd.ie
Cited by 312

Measuring network disruption in neurodegenerative diseases: new approaches using signal analysis

R McMackin, M Muthuraman, S Groppa… - Journal of Neurology …, 2019 - jnnp.bmj.com
Advanced neuroimaging has increased understanding of the pathogenesis and spread of
disease, and offered new therapeutic targets. MRI and positron emission tomography have …

[HTML][HTML] Neurophysiological markers of network dysfunction in neurodegenerative diseases

R McMackin, P Bede, N Pender, O Hardiman… - NeuroImage: Clinical, 2019 - Elsevier
There is strong clinical, imaging and pathological evidence that neurodegeneration is
associated with altered brain connectivity. While functional imaging (fMRI) can detect resting …

Patterned functional network disruption in amyotrophic lateral sclerosis

S Dukic, R McMackin, T Buxo, A Fasano… - Human Brain …, 2019 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting motor function, with additional evidence of extensive nonmotor involvement …

Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis

S Dukic, R McMackin, E Costello, M Metzger, T Buxo… - Brain, 2022 - academic.oup.com
Amyotrophic lateral sclerosis is a devastating disease characterized primarily by motor
system degeneration, with clinical evidence of cognitive and behavioural change in up to …

Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study

E Costello, J Rooney, M Pinto-Grau, T Burke… - Journal of Neurology …, 2021 - jnnp.bmj.com
Background Amyotrophic lateral sclerosis (ALS) is often associated with cognitive and/or
behavioural impairment. Cognitive reserve (CR) may play a protective role in offsetting …

Biomarkers in amyotrophic lateral sclerosis: current status and future prospects

R McMackin, P Bede, C Ingre, A Malaspina… - Nature Reviews …, 2023 - nature.com
Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …

Functional network dynamics revealed by EEG microstates reflect cognitive decline in amyotrophic lateral sclerosis

M Metzger, S Dukic, R McMackin, E Giglia… - Human Brain …, 2024 - Wiley Online Library
Recent electroencephalography (EEG) studies have shown that patterns of brain activity can
be used to differentiate amyotrophic lateral sclerosis (ALS) and control groups. These …

[HTML][HTML] Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis

R McMackin, S Dukic, E Costello, M Pinto-Grau… - Neurobiology of …, 2021 - Elsevier
We aimed to quantitatively characterize progressive brain network disruption in Amyotrophic
Lateral Sclerosis (ALS) during cognition using the mismatch negativity (MMN), an …

[HTML][HTML] Dysfunction of attention switching networks in amyotrophic lateral sclerosis

R McMackin, S Dukic, M Broderick, PM Iyer… - NeuroImage: Clinical, 2019 - Elsevier
Objective To localise and characterise changes in cognitive networks in Amyotrophic Lateral
Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms. Rationale …

[HTML][HTML] Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS

R McMackin, Y Tadjine, A Fasano, M Mitchell… - Clinical …, 2024 - Elsevier
Objective To establish if induced current direction across the motor cortex alters the
sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical …