Background Free radical accumulation and oxidative stress have been proposed as
contributing to the progression of amyotrophic lateral sclerosis (or motor neuron disease). A …

Free radical accumulation and oxidative stress have been proposed as contributing to the
progression of amyotrophic lateral sclerosis (motor neuron disease). A range of antioxidant …

The skeletal muscle ryanodine receptor plays a crucial role in excitation–contraction (EC)
coupling and is implicated in various congenital myopathies. The periodic paralyses are a …

It has been shown previously that some patients with chronic fatigue syndrome show an
abnormal increase in plasma lactate following a short period of moderate exercise, in the …

OBJECTIVES To examine the proportions of type 1 and type 2 muscle fibres and the degree
of muscle fibre atrophy and hypertrophy in patients with chronic fatigue syndrome in relation …

Serum acetylcholine receptor antibodies were measured serially in myasthenia gravis
patients before and after early extended thymectomy; they received no medication …

Five to ten percent of patients with ALS have a family history of the disease, inheritance is
usually autosomal dominant. Mutations of the SOD1 gene were first identified in a proportion …

When a patient presents with a neurological or neuromuscular disorder, it is essential to
consider drugs as a possible cause. Drugs can affect virtually any part of the neuraxis and …

AimTo outline the pathways a cohort of first attendees to our headache clinics had taken
over the years in search of explanations and treatment for their headaches. To establish a …

Clinical, electrophysiological, and molecular genetic features were investigated in two
patients from a family a with dominantly inherited myotonic disease, characterised by painful …