[HTML][HTML] Cell replacement therapy for Parkinson's disease

R Wijeyekoon, RA Barker - Biochimica et Biophysica Acta (BBA)-Molecular …, 2009 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the
degeneration of dopaminergic neurons projecting from the substantia nigra to the striatum is …

S erum immune markers and disease progression in an incident P arkinson's disease cohort (ICICLE‐PD)

CH Williams‐Gray, R Wijeyekoon… - Movement …, 2016 - Wiley Online Library
Background The immune system is a promising therapeutic target for disease modification in
Parkinson's disease (PD), but appropriate immune‐related biomarkers must be identified to …

Genetic risk of Parkinson disease and progression: an analysis of 13 longitudinal cohorts

H Iwaki, C Blauwendraat, HL Leonard, G Liu… - Neurology …, 2019 - AAN Enterprises
Objective To determine if any association between previously identified alleles that confer
risk for Parkinson disease and variables measuring disease progression. Methods We …

Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts

H Iwaki, C Blauwendraat, HL Leonard… - Movement …, 2019 - Wiley Online Library
Background Several reports have identified different patterns of Parkinson's disease
progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall …

Differences in the presentation and progression of Parkinson's disease by sex

H Iwaki, C Blauwendraat, HL Leonard… - Movement …, 2021 - Wiley Online Library
Background Previous studies reported various symptoms of Parkinson's disease (PD)
associated with sex. Some were conflicting or confirmed in only one study. Objectives We …

[HTML][HTML] Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease

RS Wijeyekoon, D Kronenberg-Versteeg… - Brain, behavior, and …, 2020 - Elsevier
The innate immune system is implicated in Parkinson's disease (PD), but peripheral in-vivo
clinical evidence of the components and driving mechanisms involved and their relationship …

[HTML][HTML] The peripheral inflammatory response to alpha-synuclein and endotoxin in Parkinson's disease

AJ White, RS Wijeyekoon, KM Scott… - Frontiers in …, 2018 - frontiersin.org
The immune system is activated in Parkinson's Disease (PD), as evidenced by
neuroinflammatory changes within the brain as well as elevated immune markers in …

α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function

WL Kuan, N Bennett, X He, JN Skepper… - Experimental …, 2016 - Elsevier
Recently it has been shown that there is impaired cerebral endothelial function in many
chronic neurodegenerative disorders including Alzheimer's and Huntington's disease. Such …

[HTML][HTML] Monocyte function in Parkinson's disease and the impact of autologous serum on phagocytosis

RS Wijeyekoon, D Kronenberg-Versteeg… - Frontiers in …, 2018 - frontiersin.org
Background: Increasing evidence implicates involvement of the innate immune system in the
initiation and progression of Parkinson's disease (PD). Monocytes and monocyte-derived …

Cerebrospinal Fluid Cytokines and Neurodegeneration‐Associated Proteins in Parkinson's Disease

RS Wijeyekoon, SF Moore, K Farrell… - Movement …, 2020 - Wiley Online Library
Introduction Immune markers are altered in Parkinson's disease (PD), but relationships
between cerebrospinal fluid (CSF) and plasma cytokines and associations with …