[HTML][HTML] Cell replacement therapy for Parkinson's disease
R Wijeyekoon, RA Barker - Biochimica et Biophysica Acta (BBA)-Molecular …, 2009 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the
degeneration of dopaminergic neurons projecting from the substantia nigra to the striatum is …
degeneration of dopaminergic neurons projecting from the substantia nigra to the striatum is …
S erum immune markers and disease progression in an incident P arkinson's disease cohort (ICICLE‐PD)
CH Williams‐Gray, R Wijeyekoon… - Movement …, 2016 - Wiley Online Library
Background The immune system is a promising therapeutic target for disease modification in
Parkinson's disease (PD), but appropriate immune‐related biomarkers must be identified to …
Parkinson's disease (PD), but appropriate immune‐related biomarkers must be identified to …
Genetic risk of Parkinson disease and progression: an analysis of 13 longitudinal cohorts
Objective To determine if any association between previously identified alleles that confer
risk for Parkinson disease and variables measuring disease progression. Methods We …
risk for Parkinson disease and variables measuring disease progression. Methods We …
Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts
Background Several reports have identified different patterns of Parkinson's disease
progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall …
progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall …
Differences in the presentation and progression of Parkinson's disease by sex
Background Previous studies reported various symptoms of Parkinson's disease (PD)
associated with sex. Some were conflicting or confirmed in only one study. Objectives We …
associated with sex. Some were conflicting or confirmed in only one study. Objectives We …
[HTML][HTML] Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease
RS Wijeyekoon, D Kronenberg-Versteeg… - Brain, behavior, and …, 2020 - Elsevier
The innate immune system is implicated in Parkinson's disease (PD), but peripheral in-vivo
clinical evidence of the components and driving mechanisms involved and their relationship …
clinical evidence of the components and driving mechanisms involved and their relationship …
[HTML][HTML] The peripheral inflammatory response to alpha-synuclein and endotoxin in Parkinson's disease
AJ White, RS Wijeyekoon, KM Scott… - Frontiers in …, 2018 - frontiersin.org
The immune system is activated in Parkinson's Disease (PD), as evidenced by
neuroinflammatory changes within the brain as well as elevated immune markers in …
neuroinflammatory changes within the brain as well as elevated immune markers in …
α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function
Recently it has been shown that there is impaired cerebral endothelial function in many
chronic neurodegenerative disorders including Alzheimer's and Huntington's disease. Such …
chronic neurodegenerative disorders including Alzheimer's and Huntington's disease. Such …
[HTML][HTML] Monocyte function in Parkinson's disease and the impact of autologous serum on phagocytosis
RS Wijeyekoon, D Kronenberg-Versteeg… - Frontiers in …, 2018 - frontiersin.org
Background: Increasing evidence implicates involvement of the innate immune system in the
initiation and progression of Parkinson's disease (PD). Monocytes and monocyte-derived …
initiation and progression of Parkinson's disease (PD). Monocytes and monocyte-derived …
Cerebrospinal Fluid Cytokines and Neurodegeneration‐Associated Proteins in Parkinson's Disease
RS Wijeyekoon, SF Moore, K Farrell… - Movement …, 2020 - Wiley Online Library
Introduction Immune markers are altered in Parkinson's disease (PD), but relationships
between cerebrospinal fluid (CSF) and plasma cytokines and associations with …
between cerebrospinal fluid (CSF) and plasma cytokines and associations with …