User profiles for "author:Ryosuke Takahashi"

Ryosuke Takahashi

Professor of Neurology, Kyoto University Graduate School of Medicine
Verified email at kuhp.kyoto-u.ac.jp
Cited by 43873

[HTML][HTML] X-linked IAP is a direct inhibitor of cell-death proteases

QL Deveraux, R Takahashi, GS Salvesen, JC Reed - Nature, 1997 - nature.com
The inhibitor-of-apoptosis (IAP) family of genes has an evolutionarily conserved role in
regulating programmed cell death in animals ranging from insects to humans,,,,,. Ectopic …

[HTML][HTML] The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases

N Roy, QL Deveraux, R Takahashi, GS Salvesen… - The EMBO …, 1997 - embopress.org
The inhibitor of apoptosis (IAP) family of proteins are highly conserved through evolution.
However, the mechanisms by which these proteins interfere with apoptotic cell death have …

[HTML][HTML] A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

Y Suzuki, Y Imai, H Nakayama, K Takahashi, K Takio… - Molecular cell, 2001 - cell.com
X chromosome-linked inhibitor of apoptosis (XIAP) is an endogenous inhibitor of caspase-3,-
7, and-9. Smac/DIABLO, an inhibitor of XIAP, is released from mitochondria upon receiving …

[HTML][HTML] An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

Y Imai, M Soda, H Inoue, N Hattori, Y Mizuno… - Cell, 2001 - cell.com
A putative G protein-coupled transmembrane polypeptide, named Pael receptor, was
identified as an interacting protein with Parkin, a gene product responsible for autosomal …

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

K Yamanaka, SJ Chun, S Boillee… - Nature …, 2008 - nature.com
Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an
adult-onset neurodegenerative disease that is characterized by the loss of motor neurons …

[HTML][HTML] Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Y Imai, M Soda, R Takahashi - Journal of Biological Chemistry, 2000 - ASBMB
Autosomal recessive juvenile parkinsonism (AR-JP) is caused by mutations in the
parkingene. Parkin protein is characterized by a ubiquitin-like domain at its NH 2-terminus …

[HTML][HTML] A single BIR domain of XIAP sufficient for inhibiting caspases

R Takahashi, Q Deveraux, I Tamm, K Welsh… - Journal of Biological …, 1998 - ASBMB
The inhibitor of apoptosis proteins (IAPs) constitute an evolutionarily conserved family of
homologous proteins that suppress apoptosis induced by multiple stimuli. Some IAP family …

[PDF][PDF] Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

T Kondo, M Asai, K Tsukita, Y Kutoku, Y Ohsawa… - Cell stem cell, 2013 - cell.com
Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the
pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here …

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas …

Y Suzuki, Y Nakabayashi… - Proceedings of the …, 2001 - National Acad Sciences
The inhibitor of apoptosis (IAP) family of anti-apoptotic proteins regulate programmed cell
death and/or apoptosis. One such protein, X-linked IAP (XIAP), inhibits the activity of the cell …

Value of in vivo α‐synuclein deposits in Parkinson's disease: A systematic review and meta‐analysis

K Tsukita, H Sakamaki‐Tsukita, K Tanaka… - Movement …, 2019 - Wiley Online Library
Previous studies that have investigated the potential of in vivo abnormal α‐synuclein
deposits as a pathological biomarker for PD included few participants and reported different …