User profiles for "author:S Brandner"

Sebastian Brandner

Professor of Neuropathology, UCL
Verified email at ucl.ac.uk
Cited by 32494

One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a …

…, A McEvoy, SM Sisodiya, S Brandner - … of Neuropathology & …, 2011 - academic.oup.com
Simple and complex forms of dysembryoplastic neuroepithelial tumors (DNTs) are readily
recognizable but forms with diffuse growth pattern, and hybrid tumors, that is, mixed DNT …

DNA methylation-based classification of central nervous system tumours

…, DW Ellison, M Hasselblatt, M Snuderl, S Brandner… - Nature, 2018 - nature.com
Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system …

[HTML][HTML] Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery

…, C Koriath, R Sciot, S Mead, S Brandner - Acta …, 2018 - Springer
Amyloid-β (Aβ) is a peptide deposited in the brain parenchyma in Alzheimer's disease and
in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA). Aβ pathology is …

Invited Review: The role of prion‐like mechanisms in neurodegenerative diseases

Z Jaunmuktane, S Brandner - Neuropathology and Applied …, 2020 - Wiley Online Library
The prototype of transmissible neurodegenerative proteinopathies is prion diseases,
characterized by aggregation of abnormally folded conformers of the native prion protein. A …

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

…, JR Hodges, MG Spillantini, T Thusgaard, S Brandner… - Nature …, 2005 - nature.com
We have previously reported a large Danish pedigree with autosomal dominant
frontotemporal dementia (FTD) linked to chromosome 3 (FTD3). Here we identify a mutation …

Normal host prion protein necessary for scrapie-induced neurotoxicity

S Brandner, S Isenmann, A Raeber, M Fischer, A Sailer… - Nature, 1996 - nature.com
ACCUMULATION of the prion protein PrPSc, a pathological and protease-resistant isoform
of the normal host protein PrPc, is a feature of prion disease such as scrapie1, 2. It is still …

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study

…, C Barbato, F Bonneville, S Brandner… - The Lancet …, 2022 - thelancet.com
Background Cerebral amyloid angiopathy (CAA) is an age-related small vessel disease,
characterised pathologically by progressive deposition of amyloid β in the cerebrovascular …

Prion protein (PrP) with amino‐proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

…, A Sailer, M Moser, B Oesch, S Brandner… - The EMBO …, 1996 - embopress.org
The 'protein only'hypothesis postulates that the prion, the agent causing transmissible
spongiform encephalopathies, is PrP (Sc), an isoform of the host protein PrP (C). Protease …

GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling

…, X Bao, N Anastasov, J Kössl, S Brandner… - ACS central …, 2019 - ACS Publications
Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and
glutathione levels to degenerative processes and tumor suppression. By performing a …

[HTML][HTML] Sarcoma classification by DNA methylation profiling

…, P Wesseling, WNM Dinjens, S Brandner… - Nature …, 2021 - nature.com
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some …