Mouse anti-Fas monoclonal antibody has a cytolytic activity on human cells that express the
antigen. Complementary DNAs encoding the cell surface antigen Fas were isolated from a …

The cellular protein retinoic acid-inducible gene I (RIG-I) senses intracellular viral infection
and triggers a signal for innate antiviral responses including the production of type I IFN. RIG …

Diagnosis of pancreatic cancer (PC) at an early stage with curative surgery is the approach
with the potential to significantly improve long-term patient outcome. Recently, some reports …

We have prepared an mAb specific for a human cell surface component (termed anti-Fas
mAb). Anti-Fas shows cell-killing activity that is indistinguishable from the cytolytic activity of …

The cell surface Fas antigen is a membrane-associated polypeptide which can mediate
apoptosis. cDNA clones encoding the Fas antigen were isolated from a cDNA library …

The small guanosine triphosphatases (GTPases) Cdc42 and Rac1 regulate E-cadherin–
mediated cell-cell adhesion. IQGAP1, a target of Cdc42 and Rac1, was localized with E …

Two novel synthetic tetrapeptides, VEID-CHO and DMQD-CHO, could selectively inhibit
caspase-6 and caspase-3, respectively. We used these inhibitors to dissect the pathway of …

Summary Budding yeast Cdc13, Stn1, and Ten1 form the CST complex to protect telomeres
from lethal DNA degradation. It remains unknown whether similar complexes are conserved …

Perforin-and Fas-based cytolytic pathways are two major mechanisms of cell-mediated
cytotoxicity. Recently, we have shown that an inhibitor of vacuolar type H+-ATPase …

ASK1 activates JNK and p38 mitogen-activated protein kinases and constitutes a pivotal
signaling pathway in cytokine-and stress-induced apoptosis. However, little is known about …