Nucleic acid‐based therapeutics that regulate gene expression have been developed
towards clinical use at a steady pace for several decades, but in recent years the field has …

Background Amyloid-β (Aβ) plaque formation is a hallmark of Alzheimer's disease (AD) and
precedes the onset of dementia. Aβ imaging should allow earlier diagnosis, but clinical …

Double-stranded RNA (dsRNA)-specific adenosine deaminase converts adenosine to
inosine in dsRNA. The protein has been purified from calf thymus, and here we describe the …

In this study we demonstrate, at an ultrastructural level, the in situ distribution of
heterogeneous nuclear RNA transcription sites after microinjection of 5-bromo-UTP (BrUTP) …

The limb girdle muscular dystrophies (LGMDs) are a group of disorders with wide genetic
and clinical heterogeneity. Recently, mutations in the ANO5 gene, which encodes a putative …

Curcumin binds to the amyloid β peptide (Aβ) and inhibits or modulates amyloid precursor
protein (APP) metabolism. Therefore, curcumin‐derived isoxazoles and pyrazoles were …

Duchenne muscular dystrophy (DMD) is caused by mutations in the X-linked dystrophin
(DMD) gene. The absence of dystrophin protein leads to progressive muscle weakness and …

Neuromuscular junctions (NMJs) are synapses that transmit impulses from motor neurons to
skeletal muscle fibers leading to muscle contraction. Study of hereditary disorders of …

Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13–p12
cause a late-onset form of autosomal dominant inclusion body myopathy associated with …

TraG-like proteins are potential NTP hydrolases (NTPases) that are essential for DNA
transfer in bacterial conjugation. They are thought to mediate interactions between the DNA …