Coprolalia (the uttering of obscenities) is reported in approximately one-third of patients
referred to specialist clinics and usually has a mean age of onset of 14 years. Importantly, its …

Background aims Mesenchymal stem cells/marrow stromal cells (MSC) represent a
promising tool for stem cell-based clinical trials in amyotrophic lateral sclerosis (ALS). We …

Background We report the initial results from a phase I clinical trial for ALS. We transplanted
GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the …

Ictal alterations of the level of general awareness and subjective content of consciousness
play a pivotal role in the clinical phenomenology of epilepsy, and reflect the pathological …

Background Tourette syndrome (TS) is a chronic neurodevelopmental disorder
characterised by the presence of multiple motor and phonic tics. Recent brain imaging …

Objective Perampanel (PER) is indicated as adjunctive antiseizure medication (ASM) in
adolescents and adults with epilepsy. Data from clinical trials show good efficacy and …

Virtually no neurologist nor psychiatrist today can be unaware of the diagnosis of Gilles de la
Tourette syndrome (GTS). Although the eponymous description by Dr. Georges Gilles de la …

The aim of this study was to determine if blood chitotriosidase (Chit) activity and lysosomal
enzyme levels might represent markers of disease activity and progression in amyotrophic …

Objective Nearly half of people with epilepsy (PWE) are expected to develop seizure
clusters (SC), with the subsequent risk of hospitalization. The aim of the present study was to …

Amyotrophic lateral sclerosis (ALS) is a devastating incurable neurodegenerative disease
that targets motor neurons, manifesting as a linear decline in muscular function and leading …