User profiles for "author:Shibeshih Belachew"
Shibeshih Mitiku BelachewBiogen Verified email at biogen.com Cited by 13598 |
Neurotransmitters as early signals for central nervous system development
During brain ontogenesis, the temporal and spatial generation of the different types of
neuronal and glial cells from precursors occurs as a sequence of successive progenitor …
neuronal and glial cells from precursors occurs as a sequence of successive progenitor …
Cell “circadian” cycle: new role for mammalian core clock genes
L Borgs, P Beukelaers, R Vandenbosch, S Belachew… - Cell Cycle, 2009 - Taylor & Francis
In mammals, 24 hours rhythms are organized as a biochemical network of molecular clocks
that are operative in all tissues, with the master clock residing in the hypothalamic …
that are operative in all tissues, with the master clock residing in the hypothalamic …
[HTML][HTML] Ocrelizumab versus placebo in primary progressive multiple sclerosis
Background An evolving understanding of the immunopathogenesis of multiple sclerosis
suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a …
suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a …
[HTML][HTML] Ocrelizumab versus interferon beta-1a in relapsing multiple sclerosis
Background B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a
humanized monoclonal antibody that selectively depletes CD20+ B cells. Methods In two …
humanized monoclonal antibody that selectively depletes CD20+ B cells. Methods In two …
Is multiple sclerosis a length-dependent central axonopathy? The case for therapeutic lag and the asynchronous progressive MS hypotheses
Trials of anti-inflammatory therapies in non-relapsing progressive multiple sclerosis (MS)
have been stubbornly negative except recently for an anti-CD20 therapy in primary …
have been stubbornly negative except recently for an anti-CD20 therapy in primary …
Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons
S Belachew, R Chittajallu, AA Aguirre, X Yuan… - The Journal of cell …, 2003 - rupress.org
Neurogenesis is known to persist in the adult mammalian central nervous system (CNS).
The identity of the cells that generate new neurons in the postnatal CNS has become a …
The identity of the cells that generate new neurons in the postnatal CNS has become a …
[HTML][HTML] Elongator controls the migration and differentiation of cortical neurons through acetylation of α-tubulin
C Creppe, L Malinouskaya, ML Volvert, M Gillard… - Cell, 2009 - cell.com
The generation of cortical projection neurons relies on the coordination of radial migration
with branching. Here, we report that the multisubunit histone acetyltransferase Elongator …
with branching. Here, we report that the multisubunit histone acetyltransferase Elongator …
Anti–JC virus antibody levels in serum or plasma further define risk of natalizumab‐associated progressive multifocal leukoencephalopathy
T Plavina, M Subramanyam, G Bloomgren… - Annals of …, 2014 - Wiley Online Library
Objective The increased risk of progressive multifocal leukoencephalopathy (PML) with
natalizumab treatment is associated with the presence of anti–JC virus (JCV) antibodies. We …
natalizumab treatment is associated with the presence of anti–JC virus (JCV) antibodies. We …
The anti‐epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA‐and glycine‐gated currents
In this study in vitro and in vivo approaches were combined in order to investigate if the anti‐
epileptic mechanism (s) of action of levetiracetam (LEV; Keppraź) may involve modulation …
epileptic mechanism (s) of action of levetiracetam (LEV; Keppraź) may involve modulation …
Contribution of relapse-independent progression vs relapse-associated worsening to overall confirmed disability accumulation in typical relapsing multiple sclerosis in …
Importance Accumulation of disability in multiple sclerosis may occur as relapse-associated
worsening (RAW) or steady progression independent of relapse activity (PIRA), with PIRA …
worsening (RAW) or steady progression independent of relapse activity (PIRA), with PIRA …