User profiles for "author:Shibeshih Belachew"

Shibeshih Mitiku Belachew

Biogen
Verified email at biogen.com
Cited by 13598

Neurotransmitters as early signals for central nervous system development

L Nguyen, JM Rigo, V Rocher, S Belachew… - Cell and tissue …, 2001 - Springer
During brain ontogenesis, the temporal and spatial generation of the different types of
neuronal and glial cells from precursors occurs as a sequence of successive progenitor …

Cell “circadian” cycle: new role for mammalian core clock genes

L Borgs, P Beukelaers, R Vandenbosch, S Belachew… - Cell Cycle, 2009 - Taylor & Francis
In mammals, 24 hours rhythms are organized as a biochemical network of molecular clocks
that are operative in all tissues, with the master clock residing in the hypothalamic …

[HTML][HTML] Ocrelizumab versus placebo in primary progressive multiple sclerosis

X Montalban, SL Hauser, L Kappos… - New england journal …, 2017 - Mass Medical Soc
Background An evolving understanding of the immunopathogenesis of multiple sclerosis
suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a …

[HTML][HTML] Ocrelizumab versus interferon beta-1a in relapsing multiple sclerosis

SL Hauser, A Bar-Or, G Comi… - … England Journal of …, 2017 - Mass Medical Soc
Background B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a
humanized monoclonal antibody that selectively depletes CD20+ B cells. Methods In two …

Is multiple sclerosis a length-dependent central axonopathy? The case for therapeutic lag and the asynchronous progressive MS hypotheses

G Giovannoni, G Cutter, MP Sormani… - Multiple sclerosis and …, 2017 - Elsevier
Trials of anti-inflammatory therapies in non-relapsing progressive multiple sclerosis (MS)
have been stubbornly negative except recently for an anti-CD20 therapy in primary …

Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons

S Belachew, R Chittajallu, AA Aguirre, X Yuan… - The Journal of cell …, 2003 - rupress.org
Neurogenesis is known to persist in the adult mammalian central nervous system (CNS).
The identity of the cells that generate new neurons in the postnatal CNS has become a …

[HTML][HTML] Elongator controls the migration and differentiation of cortical neurons through acetylation of α-tubulin

C Creppe, L Malinouskaya, ML Volvert, M Gillard… - Cell, 2009 - cell.com
The generation of cortical projection neurons relies on the coordination of radial migration
with branching. Here, we report that the multisubunit histone acetyltransferase Elongator …

Anti–JC virus antibody levels in serum or plasma further define risk of natalizumab‐associated progressive multifocal leukoencephalopathy

T Plavina, M Subramanyam, G Bloomgren… - Annals of …, 2014 - Wiley Online Library
Objective The increased risk of progressive multifocal leukoencephalopathy (PML) with
natalizumab treatment is associated with the presence of anti–JC virus (JCV) antibodies. We …

The anti‐epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA‐and glycine‐gated currents

JM Rigo, G Hans, L Nguyen, V Rocher… - British journal of …, 2002 - Wiley Online Library
In this study in vitro and in vivo approaches were combined in order to investigate if the anti‐
epileptic mechanism (s) of action of levetiracetam (LEV; Keppraź) may involve modulation …

Contribution of relapse-independent progression vs relapse-associated worsening to overall confirmed disability accumulation in typical relapsing multiple sclerosis in …

L Kappos, JS Wolinsky, G Giovannoni… - JAMA …, 2020 - jamanetwork.com
Importance Accumulation of disability in multiple sclerosis may occur as relapse-associated
worsening (RAW) or steady progression independent of relapse activity (PIRA), with PIRA …