Sweating on the palm and sole: physiological and clinical relevance

M Asahina, A Poudel, S Hirano - Clinical Autonomic Research, 2015 - Springer
In mammals, sweating is a multifunctional response that aids in locomotion, thermal
regulation, self-protection, and communication of psychological state. Humans possess …

Parkinson's disease tremor-related metabolic network: characterization, progression, and treatment effects

H Mure, S Hirano, CC Tang, IU Isaias, A Antonini, Y Ma… - Neuroimage, 2011 - Elsevier
The circuit changes that mediate parkinsonian tremor, while likely differing from those
underlying akinesia and rigidity, are not precisely known. In this study, to identify a specific …

Functional brain imaging of cognitive dysfunction in Parkinson's disease

S Hirano, H Shinotoh, D Eidelberg - Journal of Neurology …, 2012 - jnnp.bmj.com
Multiple factors are involved in the development of cognitive impairment in Parkinson's
disease (PD) and related disorders. Notably, several underlying factors, such as …

Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates

Y Murakami, M Ogasawara, F Sugahara, S Hirano… - 2001 - journals.biologists.com
The Pax6 gene plays a developmental role in various metazoans as the master regulatory
gene for eye patterning. Pax6 is also spatially regulated in particular regions of the neural …

Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution

S Hirano, T Sato, T Narita, K Kusunoki, N Ozaki… - Journal of affective …, 2002 - Elsevier
Background: Little is known as to whether or not the seven personality dimensions of
Cloninger's theory, particularly the three character dimensions newly included in the theory …

Heterotopic shift of epithelial-mesenchymal interactions in vertebrate jaw evolution

Y Shigetani, F Sugahara, Y Kawakami, Y Murakami… - Science, 2002 - science.org
Genes involved in late specification of the mandibular arch, the source of the vertebrate jaw,
are expressed with similar patterns in the oral regions of chick and lamprey embryos …

Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease

S Hirano, K Asanuma, Y Ma, C Tang… - Journal of …, 2008 - Soc Neuroscience
We compared the metabolic and neurovascular effects of levodopa (LD) therapy for
Parkinson's disease (PD). Eleven PD patients were scanned with both [15O]-H2O and [18F] …

Apathy correlates with prefrontal amyloid β deposition in Alzheimer's disease

T Mori, H Shimada, H Shinotoh, S Hirano… - Journal of Neurology …, 2014 - jnnp.bmj.com
Objective Neuropsychiatric symptoms affect many patients with Alzheimer's disease
(AD).(11C) Pittsburgh Compound-B (PIB) positron emission tomography (PET) has enabled …

[HTML][HTML] Clinical implications for dopaminergic and functional neuroimage research in cognitive symptoms of Parkinson's disease

S Hirano - Molecular Medicine, 2021 - Springer
Evidence from dopaminergic image and cerebral blood flow/metabolism images have shed
light on symptomatology of cognitive aspects in brain physiology of healthy human as well …

[HTML][HTML] Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

H Matsuda, M Murata, Y Mukai, K Sako, H Ono… - European journal of …, 2018 - Springer
Purpose The aim of this multicenter trial was to generate a [123 I] FP-CIT SPECT database
of healthy controls from the common SPECT systems available in Japan. Methods This study …