Alzheimer's disease (AD) has characteristic histopathological, molecular, and biochemical
abnormalities, including cell loss; abundant neurofibrillary tangles; dystrophic neurites; …

The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

Interest in characterizing the role of impaired insulin actions in Alzheimer's disease (AD) and
vascular dementia is growing exponentially. This review details what is currently known …

The neurodegeneration that occurs in sporadic Alzheimer's disease (AD) is consistently
associated with a number of characteristic histopathological, molecular, and biochemical …

Abstract Cyclin-dependent kinase 5 (Cdk5) is required for proper development of the
mammalian central nervous system. To be activated, Cdk5 has to associate with its …

Reduced glucose utilization and energy metabolism occur early in the course of Alzheimer's
disease (AD) and correlate with impaired cognition. Glucose utilization and energy …

The cascade of Alzheimer's disease (AD) neurodegeneration is associated with persistent
oxidative stress, mitochondrial dysfunction, impaired energy metabolism, and activation of …

The development and maintenance of the vertebrate nervous system depends upon
neuronal survival proteins known as neurotrophic factors. Nerve growth factor (NGF) …

Mutations of the p53 gene are found in hepatocellular carcinoma (HCC), the most common
form of primary liver cancer. Specific mutations might reflect exposure to specific …

Emerging data demonstrate pivotal roles for brain insulin resistance and insulin deficiency
as mediators of cognitive impairment and neurodegeneration, particularly Alzheimer's …