Alzheimer's disease is type 3 diabetes—evidence reviewed
SM De la Monte, JR Wands - Journal of diabetes science …, 2008 - journals.sagepub.com
Alzheimer's disease (AD) has characteristic histopathological, molecular, and biochemical
abnormalities, including cell loss; abundant neurofibrillary tangles; dystrophic neurites; …
abnormalities, including cell loss; abundant neurofibrillary tangles; dystrophic neurites; …
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease
SM de la Monte, JR Wands - Journal of Alzheimer's Disease, 2005 - content.iospress.com
Interest in characterizing the role of impaired insulin actions in Alzheimer's disease (AD) and
vascular dementia is growing exponentially. This review details what is currently known …
vascular dementia is growing exponentially. This review details what is currently known …
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease–is this type 3 diabetes?
E Steen, BM Terry, EJ Rivera… - Journal of …, 2005 - content.iospress.com
The neurodegeneration that occurs in sporadic Alzheimer's disease (AD) is consistently
associated with a number of characteristic histopathological, molecular, and biochemical …
associated with a number of characteristic histopathological, molecular, and biochemical …
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
GN Patrick, L Zukerberg, M Nikolic, S de La Monte… - Nature, 1999 - nature.com
Abstract Cyclin-dependent kinase 5 (Cdk5) is required for proper development of the
mammalian central nervous system. To be activated, Cdk5 has to associate with its …
mammalian central nervous system. To be activated, Cdk5 has to associate with its …
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine
EJ Rivera, A Goldin, N Fulmer… - Journal of …, 2005 - content.iospress.com
Reduced glucose utilization and energy metabolism occur early in the course of Alzheimer's
disease (AD) and correlate with impaired cognition. Glucose utilization and energy …
disease (AD) and correlate with impaired cognition. Glucose utilization and energy …
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease
N Lester-Coll, EJ Rivera, SJ Soscia… - Journal of …, 2006 - content.iospress.com
The cascade of Alzheimer's disease (AD) neurodegeneration is associated with persistent
oxidative stress, mitochondrial dysfunction, impaired energy metabolism, and activation of …
oxidative stress, mitochondrial dysfunction, impaired energy metabolism, and activation of …
Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations
PC Maisonpierre, MM Le Beau, R Espinosa III, NY Ip… - Genomics, 1991 - Elsevier
The development and maintenance of the vertebrate nervous system depends upon
neuronal survival proteins known as neurotrophic factors. Nerve growth factor (NGF) …
neuronal survival proteins known as neurotrophic factors. Nerve growth factor (NGF) …
p53 mutation in hepatocellular carcinoma after aflatoxin exposure
B Bressac, A Puisieux, M Kew, M Volkmann, S Bozcall… - The Lancet, 1991 - Elsevier
Mutations of the p53 gene are found in hepatocellular carcinoma (HCC), the most common
form of primary liver cancer. Specific mutations might reflect exposure to specific …
form of primary liver cancer. Specific mutations might reflect exposure to specific …
[HTML][HTML] Insulin resistance and Alzheimer's disease
SM De La Monte - BMB reports, 2009 - ncbi.nlm.nih.gov
Emerging data demonstrate pivotal roles for brain insulin resistance and insulin deficiency
as mediators of cognitive impairment and neurodegeneration, particularly Alzheimer's …
as mediators of cognitive impairment and neurodegeneration, particularly Alzheimer's …