The pathophysiology of traumatic brain (TBI) injury involves changes to glucose uptake into
the brain and its subsequent metabolism. We review the methods used to study cerebral …

Even in the absence of an experimental effect, functional magnetic resonance imaging
(fMRI) time series generally demonstrate serial dependence. This colored noise or …

It is widely held that the frontal cortex plays a critical part in certain aspects of spatial and
non‐spatial working memory. One unresolved issue is whether there are functionally distinct …

Traumatic brain injury (TBI) triggers a series of complex pathophysiological processes.
These include abnormalities in brain energy metabolism; consequent to reduced tissue pO 2 …

Objective: To use a range of techniques to explore diffusion limitation as a mechanism of
cellular hypoxia in the setting of head injury. Design: A prospective interventional study …

Interventions All subjects underwent positron emission tomography imaging of cerebral
blood flow. In patients, Paco 2 was reduced from 36±1 to 29±1 torr (4.8±0.1 to 3.9±0.1 kPa) …

Metabolic dyslipidemia is characterized by high circulating triglyceride (TG) and low HDL
cholesterol levels and is frequently accompanied by hepatic steatosis. Increased hepatic …

Microdialysis enables the chemistry of the extracellular interstitial space to be monitored.
Use of this technique in patients with acute brain injury has increased our understanding of …

Objective: To determine whether hyperventilation exacerbates cerebral ischemia and
compromises oxygen metabolism (CMRO 2) following closed head injury. Design: A …

Antemortem demonstration of ischemia has proved elusive in head injury because regional
CBF reductions may represent hypoperfusion appropriately coupled to hypometabolism …