Artemisinin and its derivatives are endoperoxide-containing compounds which represent a
promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs …

Severe malaria is commonly misdiagnosed in Africa, leading to a failure to treat other life-
threatening illnesses. In malaria-endemic areas, parasitemia does not ensure a diagnosis of …

Glioblastoma (glioblastoma multiforme; GBM; WHO Grade IV) accounts for the majority of
primary malignant brain tumors in adults. Amplification and mutation of the epidermal growth …

To investigate the role of tumor necrosis factor in Plasmodium falciparum infections, we
measured serum concentrations of this cytokine in 65 Malawian children with severe …

To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children
with this clinical diagnosis. We found that 23% of the children had actually died from other …

We studied the relationship between presenting features and outcome in 131 Malawian
children admitted with cerebral malaria (P. falciparum malaria and unrousable coma). A …

In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-
pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum …

Molecular assays for monitoring sulfadoxine-pyrimethamine-resistant Plasmodium
falciparum have not been implemented because of the genetic and statistical complexity of …

Viewpoint reduced mefloquine sensitivity is lessened substantially. 8 Second, the
artemisinin derivatives decrease gametocyte carriage by roughly 90%. 9 Recrudescent (ie …

We report a genome-wide association (GWA) study of severe malaria in The Gambia. The
initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and …