We have developed a family of unnatural base pairs (UBPs), which rely on hydrophobic and
packing interactions for pairing and which are well replicated and transcribed. While the pair …

Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a
crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM …

Background Contemporary stroke incidence data are not available in some countries and
regions, including in Eastern Europe. Based on previous validation of the accuracy of the …

Objective Exposure to contrast agents may cause nephrotoxicity. The safety of performing
CT angiography without having knowledge of the baseline creatinine level in stroke patients …

An effective analytical method for the quantification of N-nitrosodimethylamine (NDMA)
using a liquid chromatography coupled with tandem mass spectrometry was developed and …

Centrosome amplification is a hallmark of human cancers that can trigger cancer cell
invasion. To survive, cancer cells cluster amplified extra centrosomes and achieve …

The possibility of N-Nitrosation in the absence of nitrosating agents was studied on model
solutions and film coated tablets containing metformin. N-nitrosodimethylamine (NDMA) and …

As is the case with batch-based tableting processes, continuous tablet manufacturing can be
conducted by direct compression or with a granulation step such as dry or wet granulation …

The transfer from batch-based to continuous tablet manufacturing increases the quality and
efficiency of processes. Nonetheless, as in the development of a batch process, the …

2-Bromo-6-chloro-and 6-bromo-2-chloropyridin-3-yl deoxyribonucleosides were prepared
by the Heck coupling of bromo-chloro-iodopyridines with TBS-protected deoxyribose glycal …