Nuclear oncogene products have the potential to induce alterations in gene regulation
leading to the genesis of cancer. The biochemical mechanisms by which nuclear …

Two different forms of death are commonly observed when Mycobacterium tuberculosis
(Mtb)-infected macrophages die:(i) necrosis, a death modality defined by cell lysis and (ii) …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Geant4 is a toolkit for simulating the passage of particles through matter. It includes a
complete range of functionality including tracking, geometry, physics models and hits. The …

A new algorithm called Mersenne Twister (MT) is proposed for generating uniform
pseudorandom numbers. For a particular choice of parameters, the algorithm provides a …

The natural killer T (NKT) cell ligand α-galactosylceramide (α-GalCer) exhibits profound
antitumor activities in vivo that resemble interleukin (IL)-12–mediated antitumor activities …

Regulated increase in the formation of microtubule arrays is thought to be important for
axonal growth. Collapsin response mediator protein-2 (CRMP-2) is a mammalian …

Most large earthquakes occur along an oceanic trench, where an oceanic plate subducts
beneath a continental plate. Massive earthquakes with a moment magnitude, M w, of nine …

Mice lacking the gene encoding the receptor for prostaglandin F2α (FP) developed normally
but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed …

The mollusk shell is a hard tissue consisting of calcium carbonate crystals and an organic
matrix. The nacre of the shell is characterized by a stacked compartment structure with a …