Among the various disorders manifesting dementia, gait disturbance, and urinary
incontinence in the elderly population, idiopathic normal pressure hydrocephalus (iNPH) is …

There is ample biochemical, pathological, and genetic evidence that the metabolism of α-
synuclein (α-syn) plays a crucial role in the pathogenesis of Parkinson disease (PD). To …

Among the various disorders that manifest with gait disturbance, cognitive impairment, and
urinary incontinence in the elderly population, idiopathic normal pressure hydrocephalus …

Importance Parkinson disease (PD) is a highly prevalent and incurable neurodegenerative
disease associated with the accumulation of misfolded α-synuclein (αSyn) aggregates. An …

The inheritance of the apolipoprotein E (apoE) ϵ4 allele is a prevailing risk factor for
sporadic and familial Alzheimer's disease (AD). ApoE isoforms bind directly to Alzheimer's …

There is accumulating evidence that soluble amyloid‐β (Aβ) oligomers, rather than amyloid
fibrils, are the principal pathogenic species in Alzheimer disease (AD). Here, we have …

Cerebral amyloid angiopathy is commonly associated with normal aging and Alzheimer's
disease and it is also the principal feature of hereditary cerebral hemorrhage with …

Background There is still a substantial unmet need for less invasive and lower-cost blood-
based biomarkers to detect brain Alzheimer's disease (AD) pathology. This study is aimed to …

Background Despite decades of intensive research, to date, there is no accepted diagnosis
for Parkinson's disease (PD) based on biochemical analysis of blood or CSF. However …

There is mounting pathological, biochemical and genetic evidence that the metabolism and
aggregation of the 43-kDa transactive response (TAR)-DNA-binding protein (TDP-43) play a …