Amyotrophic lateral sclerosis (ALS) is a late-onset, fatal disorder in which the motor neurons
degenerate. The discovery of new drugs for treating ALS has been hampered by a lack of …

Amyotrophic lateral sclerosis (ALS), a fatal disease causing progressive loss of motor
neurons, still has no effective treatment. We developed a phenotypic screen to repurpose …

Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic
lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the …

Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is a pathological signature of
amyotrophic lateral sclerosis (ALS). Although accumulating evidence suggests the …

Parkinson's disease is one of the most common movement disorders and is characterized by
dopaminergic cell loss and the accumulation of pathological α-synuclein, but its precise …

DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates
with age, in which cytoskeletal proteins are polymerized to repair DSB in dividing cells …

Glial cytoplasmic inclusions (GCIs), commonly observed as α-synuclein (α-syn)-positive
aggregates within oligodendrocytes, are the pathological hallmark of multiple system …

Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is implicated in the
pathogenesis of sporadic and certain familial forms of amyotrophic lateral sclerosis (ALS) …

Background Mutations in the valosin-containing protein (VCP) gene were first found to
cause inclusion-body myopathy with early-onset Paget disease and frontotemporal …

Parkinson's disease is a progressive neurodegenerative disorder characterized by the
preferential loss of tyrosine hydroxylase (TH)-expressing dopaminergic neurons in the …