Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple
sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies …

Serum antibodies directed against myelin oligodendrocyte glycoprotein (MOG) are found in
patients with acquired CNS demyelinating syndromes that are distinct from multiple sclerosis …

Background: There has been tremendous growth in research in pediatric multiple sclerosis
(MS) and immune mediated central nervous system demyelinating disorders since …

The gut microbiome plays an important role in immune function and has been implicated in
several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut …

Programmed death-1 (PD-1) receptor, an inhibitory costimulatory molecule found on
activated T cells, has been demonstrated to play a role in the regulation of immune …

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory
disorder of the CNS characterized by a widespread demyelination that predominantly …

Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently
identified autoimmune disorder that presents in both adults and children as CNS …

Experimental autoimmune encephalomyelitis (EAE) is mediated by autoantigen-specific T
cells dependent on critical costimulatory signals for their full activation and regulation. We …

Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to
involve only the optic nerves and spinal cord. However, the discovery of highly specific anti …

Objective: To examine whether obesity during childhood, adolescence, or adulthood is
associated with an increased risk of multiple sclerosis (MS). Methods: Women in the Nurses' …