Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
As tumors grow, they acquire mutations, some of which create neoantigens that influence
the response of patients to immune checkpoint inhibitors. We explored the impact of …
the response of patients to immune checkpoint inhibitors. We explored the impact of …
[HTML][HTML] Tracking the evolution of non–small-cell lung cancer
M Jamal-Hanjani, GA Wilson… - … England Journal of …, 2017 - Mass Medical Soc
Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective …
heterogeneity and cancer genome evolution have been limited to small retrospective …
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …
the characterization of emerging subclones, which seed metastatic sites, might offer new …
[PDF][PDF] Allele-specific HLA loss and immune escape in lung cancer evolution
Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …
A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells
B Falini, M Fizzotti, A Pucciarini… - Blood, The Journal …, 2000 - ashpublications.org
A new monoclonal antibody (MUM1p) was used to study the cell/tissue expression of human
MUM1/IRF4 protein, the product of the homologous gene involved in the myeloma …
MUM1/IRF4 protein, the product of the homologous gene involved in the myeloma …
[HTML][HTML] The evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
MicroRNA expression distinguishes between germinal center B cell‐like and activated B cell‐like subtypes of diffuse large B cell lymphoma
CH Lawrie, S Soneji, T Marafioti… - … journal of cancer, 2007 - Wiley Online Library
Diffuse large B cell lymphoma (DLBCL) is an aggressive malignancy that accounts for nearly
40% of all lymphoid tumors. This heterogeneous disease can be divided into germinal …
40% of all lymphoid tumors. This heterogeneous disease can be divided into germinal …
[HTML][HTML] Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter
Photoacoustic imaging allows absorption-based high-resolution spectroscopic in vivo
imaging at a depth beyond that of optical microscopy. Until recently, photoacoustic imaging …
imaging at a depth beyond that of optical microscopy. Until recently, photoacoustic imaging …
A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy
B Philip, E Kokalaki, L Mekkaoui… - Blood, The Journal …, 2014 - ashpublications.org
A compact marker/suicide gene that utilizes established clinical-grade reagents and
pharmaceuticals would be of considerable practical utility to T-cell cancer gene therapy …
pharmaceuticals would be of considerable practical utility to T-cell cancer gene therapy …
European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 …
I Anagnostopoulos, ML Hansmann… - Blood, The Journal …, 2000 - ashpublications.org
Paraffin blocks and clinical data from 521 patients with lymphocyte predominance Hodgkin
disease (LPHD) diagnosed between 1970 and 1994 were collected from 16 European and …
disease (LPHD) diagnosed between 1970 and 1994 were collected from 16 European and …