User profiles for "author:Tracy R Melzer"

Tracy R Melzer

University of Otago, New Zealand Brain Research Institute
Verified email at nzbri.org
Cited by 4667

The genetic architecture of the human cerebral cortex

KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …

Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy

ML Elliott, A Caspi, RM Houts, A Ambler, JM Broadbent… - Nature aging, 2021 - nature.com
Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …

Grey matter atrophy in cognitively impaired Parkinson's disease

TR Melzer, R Watts, MR MacAskill… - Journal of Neurology …, 2012 - jnnp.bmj.com
Objective Mild cognitive impairment and dementia are common non-motor features of
Parkinson's disease (PD). The aim of this study was to characterise grey matter changes …

[HTML][HTML] General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks

ML Elliott, AR Knodt, M Cooke, MJ Kim, TR Melzer… - Neuroimage, 2019 - Elsevier
Intrinsic connectivity, measured using resting-state fMRI, has emerged as a fundamental tool
in the study of the human brain. However, due to practical limitations, many studies do not …

Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease

TR Melzer, R Watts, MR MacAskill, JF Pearson… - Brain, 2011 - academic.oup.com
There is a need for objective imaging markers of Parkinson's disease status and
progression. Positron emission tomography and single photon emission computed …

[HTML][HTML] Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort

ML Elliott, DW Belsky, AR Knodt, D Ireland… - Molecular …, 2021 - nature.com
An individual's brainAGE is the difference between chronological age and age predicted
from machine-learning models of brain-imaging data. BrainAGE has been proposed as a …

White matter microstructure deteriorates across cognitive stages in Parkinson disease

TR Melzer, R Watts, MR MacAskill, TL Pitcher… - Neurology, 2013 - AAN Enterprises
Objectives: To characterize different stages of Parkinson disease (PD)-related cognitive
decline using diffusion tensor imaging (DTI) and investigate potential relationships between …

Characterizing mild cognitive impairment in Parkinson's disease

JC Dalrymple‐Alford, L Livingston… - Movement …, 2011 - Wiley Online Library
There is growing interest in identifying Parkinson's disease (PD) patients with mild cognitive
impairment (PD‐MCI), but widely disparate criteria have been used. We assessed 143 PD …

International multicenter analysis of brain structure across clinical stages of Parkinson's disease

MA Laansma, JK Bright, S Al‐Bachari… - Movement …, 2021 - Wiley Online Library
Background Brain structure abnormalities throughout the course of Parkinson's disease
have yet to be fully elucidated. Objective Using a multicenter approach and harmonized …

Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis

L Debernard, TR Melzer, S Van Stockum… - Journal of Neurology …, 2014 - jnnp.bmj.com
Background Grey matter (GM) pathology in multiple sclerosis (MS) is associated with
progressive long-term disability. Detection of GM abnormalities in early MS may therefore be …