Until the introduction of antibiotics in the 1930s and 1940s, acute bacterial meningitis was
fatal in most cases. Since then it has become curable with a variable mortality and morbidity …

No bacterial disease has undergone a more dramatic change in epidemiology during the
past decade than acute bacterial meningitis. This review describes the changing …

Lyme disease, caused by the Borrelia burgdorferi bacterium, is the most common vector-
borne disease in the northern hemisphere. The clinical presentation varies with disease …

Host protection from infection relies on the recognition of pathogens by innate pattern-
recognition receptors such as Toll-like receptors (TLRs). Here, we show that the orphan …

This review describes the current knowledge of the pathogenesis of acute Lyme
neuroborreliosis (LNB), from invasion to inflammation of the central nervous system. Borrelia …

Meningitis is an inflammation of the meninges and subarachnoid space that can also involve
the brain cortex and parenchyma. It can be acquired spontaneously in the community …

Heterologous expression of Toll-like receptor (TLR) 2 and CD14 in Chinese hamster ovary
fibroblasts was reported to confer responsiveness to pneumococcal peptidoglycan. The …

Streptococcus pneumoniae meningitis causes brain damage through inflammation-related
pathways whose identity and mechanisms of action are yet unclear. We previously identified …

During acute bacterial infections such as meningitis, neutrophils enter the tissue where they
combat the infection before they undergo apoptosis and are taken up by macrophages …

In this study, we investigated the involvement of matrix metalloproteinases (MMPs) in the
pathophysiology of bacterial meningitis. By using an enzyme immunoassay, high …