Alzheimer's disease (AD) is the most common cause of dementia in late life. There is still no
clear-cut consensus whether this disease involves genetic or environmental factors or both …

Until a few years ago, the anti-parkinsonian effect of amantadine hydrochloride (AHCl) and
amantadine sulfate (AS) could not be explained. The beneficial effect of amantadine, which …

The relative incidence of the major types of dementia disorders and the agreement rates
between clinical and pathological diagnosis were analysed in consecutive autopsy series of …

Dopamine appears to be of less importance in the regulation of psychomotor functions than
was previously thought. A central dopaminergic-glutamatergic balance may be important for …

Amantadine (1-amino-adamantane) is clinically used for the management of Parkinson's
disease and drug-induced extrapyramidal symptoms. It has previously been shown that …

The discovery that MAO can be differentiated biochemically and pharmacologically into two
forms, types A and B, with different substrate specificities and inhibitor sensitivities has …

We have analysed several markers for small synaptic vesicles (synaptin-synaptophysin, p65
and SV2) and large dense-core vesicles (chromogranin A, secretogranin II/chromogranin C) …

The density of nicotinic α4β2 receptors, which are believed to largely mediate nicotine's
effects, has been reported to be decreased in post-mortem hippocampus of patients with …

Adenosine A 2A receptors have been implicated in the pathophysiology of schizophrenia by
clinical, anatomical, biochemical and genetic studies. We hypothesized that a genetically …

Memantine was investigated in a phase II double-blind trial on 30 elderly patients by
comparison with a placebo with the aid of several psychometric tests. It was found that …