[HTML][HTML] Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised …

JT Yu, W Xu, CC Tan, S Andrieu, J Suckling… - Journal of Neurology …, 2020 - jnnp.bmj.com
Background Evidence on preventing Alzheimer's disease (AD) is challenging to interpret
due to varying study designs with heterogeneous endpoints and credibility. We completed a …

Blood pressure and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 209 prospective studies

YN Ou, CC Tan, XN Shen, W Xu, XH Hou, Q Dong… - …, 2020 - Am Heart Assoc
Controversies persist regarding the association between blood pressure (BP) and the risks
of cognitive impairment and dementia due to inconsistent definitions of BP exposure and …

Models for predicting risk of dementia: a systematic review

XH Hou, L Feng, C Zhang, XP Cao, L Tan… - Journal of Neurology …, 2019 - jnnp.bmj.com
Background Information from well-established dementia risk models can guide targeted
intervention to prevent dementia, in addition to the main purpose of quantifying the …

[HTML][HTML] Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer's disease: a network meta-analysis of 41 randomized …

KX Dou, MS Tan, CC Tan, XP Cao, XH Hou… - Alzheimer's research & …, 2018 - Springer
Background Cholinesterase inhibitors and memantine have been approved for
management of Alzheimer's disease (AD), but there has been no consensus about the …

[HTML][HTML] Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review

X Ji, XY Leng, Y Dong, YH Ma, W Xu… - Annals of …, 2019 - ncbi.nlm.nih.gov
Background Carotid atherosclerosis is a major cause of stroke, but the conclusion about risk
factors for carotid atherosclerosis is still controversial. The aim of our present meta-analysis …

TREM2 variants and neurodegenerative diseases: a systematic review and meta-analysis

SL Zhou, CC Tan, XH Hou, XP Cao… - Journal of Alzheimer's …, 2019 - content.iospress.com
TREM2 (triggering receptor expressed on myeloid cells 2) gene variants were reported to
increase the risk of Alzheimer's disease (AD) and even other neurodegenerative diseases …

Predictors of cognitive impairment in Parkinson's disease: a systematic review and meta-analysis of prospective cohort studies

Y Guo, FT Liu, XH Hou, JQ Li, XP Cao, L Tan… - Journal of …, 2021 - Springer
Introduction Cognitive impairment is a debilitating manifestation in Parkinson's disease (PD).
We sought to investigate predictors of PD-CI (PD with cognitive impairment). Methods We …

Neurofilament light chain in cerebrospinal fluid and blood as a biomarker for neurodegenerative diseases: a systematic review and meta-analysis

SY Wang, W Chen, W Xu, JQ Li… - Journal of …, 2019 - content.iospress.com
Background: Neurofilament light chain (NFL) as a potential biomarker of neurodegenerative
diseases has been studied in a number of studies. Thus, a comprehensive meta-analysis is …

Associations of infectious agents with Alzheimer's disease: a systematic review and meta-analysis

YN Ou, JX Zhu, XH Hou, XN Shen… - Journal of …, 2020 - content.iospress.com
Background: The role of infectious agents in the development of Alzheimer's disease (AD)
has long been debated, however, uncertainties still persist. Objective: We aimed to …

Genome-wide association study identifies Alzheimer's risk variant in MS4A6A influencing cerebrospinal fluid sTREM2 levels

XH Hou, YL Bi, MS Tan, W Xu, JQ Li, XN Shen… - Neurobiology of …, 2019 - Elsevier
The triggering receptor expressed on myeloid cells 2 (TREM2) gene has been reported to
increase the risk of Alzheimer's disease (AD). The soluble TREM2 protein (sTREM2) in …