At least eight inherited neurodegenerative diseases are caused by expanded CAG repeats
encoding polyglutamine (polyQ) stretches. Although cytotoxicities of expanded polyQ …

Background Receptor-mediated transcytosis is one of the major routes for drug delivery of
large molecules into the brain. The aim of this study was to develop a novel model of the …

Objective: To address the hypothesis that physiologic interactions between astrocytes and
endothelial cells (EC) at the blood–brain barrier (BBB) are afflicted by pathogenic …

We describe here the design and implementation of an in vitro microvascular open model
system using human brain microvascular endothelial cells. The design has several …

The destruction of blood–brain barrier (BBB) and blood-nerve barrier (BNB) has been
considered to be a key step in the disease process of a number of neurological disorders …

The objectives of this study were to establish pure blood–nerve barrier (BNB) and blood–
brain barrier (BBB)‐derived pericyte cell lines of human origin and to investigate their …

The breakdown of the blood–brain barrier (BBB) has been considered to be a key step in the
disease process of a number of neurological disorders such as cerebral ischemia and …

Neuromyelitis optica (NMO) is an inflammatory disorder mediated by antibodies to
aquaporin-4 (AQP4) with prominent blood-brain barrier (BBB) breakdown in the acute phase …

The objective of this study was to establish pure blood–nerve barrier (BNB)‐derived
peripheral nerve pericyte cell lines and to investigate their unique properties as barrier …

Diabetic encephalopathy is now accepted as an important complication of diabetes. The
breakdown of the blood–brain barrier (BBB) is associated with dementia in patients with type …