[HTML][HTML] Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration

NJ Ashton, A Leuzy, YM Lim, C Troakes… - Acta neuropathologica …, 2019 - Springer
Alzheimer's disease (AD) is pathologically characterized by the accumulation of amyloid-β
(Aβ) plaques, neurofibrillary tangles and widespread neuronal loss in the brain. In recent …

[HTML][HTML] Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation

S Badodi, N Pomella, X Zhang, G Rosser… - Nature …, 2021 - nature.com
Deregulation of chromatin modifiers plays an essential role in the pathogenesis of
medulloblastoma, the most common paediatric malignant brain tumour. Here, we identify a …

Optical properties of human brain and tumour tissue: an ex vivo study spanning the visible range to beyond the second near‐infrared window

J Shapey, Y Xie, E Nabavi, M Ebner… - Journal of …, 2022 - Wiley Online Library
Neuro‐oncology surgery would benefit from detailed intraoperative tissue characterization
provided by noncontact, contrast‐agent‐free, noninvasive optical imaging methods. In …

Cortical neuronal hypertrophy and mTOR pathway activation in CAN regions in SUDEP

S Patodia, YM Lim, F Chung, I Stylianou… - …, 2022 - Wiley Online Library
Objectives Dysfunctional connectivity and preexisting structural abnormalities of central
autonomic network (CAN) regions have been shown on magnetic resonance imaging (MRI) …

Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma

S Badodi, N Pomella, YM Lim, S Brandner… - Neuro …, 2022 - academic.oup.com
Background Epigenetic changes play a key role in the pathogenesis of medulloblastoma
(MB), the most common malignant pediatric brain tumor. Methods We explore the …

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

J Boot, G Rosser, D Kancheva, C Vinel, YM Lim… - Elife, 2022 - elifesciences.org
We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour,
harbouring a bias towards hypomethylation at defined differentially methylated regions. This …

[PDF][PDF] Generation and characterisation of an in vitro TREM2-deficient microglia model

YM Lim - 2018 - kclpure.kcl.ac.uk
Rare variants of TREM2 have been associated with increased risk of developing several
neurodegenerative diseases. In particular, the heterozygous p. R47H variant (rs75932628) …

Global hypo-methylation in a subgroup of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

JR Boot, G Rosser, D Kancheva, C Vinel, YM Lim… - bioRxiv, 2022 - biorxiv.org
We describe a new molecular subgroup of glioblastoma, the most prevalent malignant adult
brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated …

12.30 Do anticholinergic drugs increase alzheimer's pathology in parkinson's patients? A retrospective post-mortem investigation

YM Lim, RKB Pearce… - Journal of Neurology …, 2019 - search.proquest.com
Results A higher anticholinergic burden is associated with a greater tau burden in entorhinal
cortex in PD cases (OR= 2.21). Interestingly, a high anticholinergic burden decreases the …

CRISPR/Cas9 gene editing of brain cancer stem cells using lipid-based nano-delivery

N Rouatbi, YM Lim, V Grant, PM Costa… - Neuro …, 2019 - ncbi.nlm.nih.gov
Despite advances in cancer therapy glioblastoma (GBM) remains one of the deadliest brain
tumours. Effective therapy is restricted by the presence of multiple resistance mechanisms …