[HTML][HTML] Novel coronavirus disease 2019 (COVID-19) and cytokine storms for more effective treatments from an inflammatory pathophysiology

S Yokota, T Miyamae, Y Kuroiwa… - Journal of Clinical …, 2021 - mdpi.com
The Novel Coronavirus Disease 2019 (COVID-19) has swept the world and caused a global
pandemic. SARS-CoV-2 seems to have originated from bats as their reservoir hosts over …

Prospective 10-year surveillance of human prion diseases in Japan

I Nozaki, T Hamaguchi, N Sanjo, M Noguchi-Shinohara… - Brain, 2010 - academic.oup.com
We analysed the epidemiological data and clinical features of patients with prion diseases
that had been registered by the Creutzfeldt-Jakob Disease Surveillance Committee, Japan …

Clinical significance of periodic EEG patterns

Y Kuroiwa, GG Celesia - Archives of Neurology, 1980 - jamanetwork.com
• Generalized and focal periodic EEG patterns were studied in 62 patients. Generalized
periodic suppression bursts and generalized periodic slow-wave complexes (GPSC) …

The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases

H Doi, S Koyano, Y Suzuki, N Nukina, Y Kuroiwa - Neuroscience research, 2010 - Elsevier
Neuronal intranuclear inclusions (NIIs) are the pathological hallmark of polyglutamine
(polyQ) diseases. We previously found that the RNA-binding protein FUS/TLS is the major …

[HTML][HTML] RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells

H Doi, K Okamura, PO Bauer, Y Furukawa… - Journal of Biological …, 2008 - ASBMB
Formation of intracellular aggregates is the hallmark of polyglutamine (polyQ) diseases. We
analyzed the components of purified nuclear polyQ aggregates by mass spectrometry. As a …

A study of the early stage of dysphagia in amyotrophic lateral sclerosis

S Kawai, M Tsukuda, I Mochimatsu, H Enomoto… - Dysphagia, 2003 - Springer
In amyotrophic lateral sclerosis (ALS) patients, dysphagia eventually occurs independent of
time of onset. We studied dysphagia conditions in the early stage of ALS, principally at the …

Variants associated with Gaucher disease in multiple system atrophy

J Mitsui, T Matsukawa, H Sasaki, I Yabe… - Annals of clinical …, 2015 - Wiley Online Library
Objective Glucocerebrosidase gene (GBA) variants that cause Gaucher disease are
associated with Parkinson disease (PD) and dementia with Lewy bodies (DLB). To …

Reduction rate of body mass index predicts prognosis for survival in amyotrophic lateral sclerosis: a multicenter study in Japan

T Shimizu, U Nagaoka, Y Nakayama… - Amyotrophic Lateral …, 2012 - Taylor & Francis
Malnutrition in the early stage has been reported as an independent predictor of survival in
amyotrophic lateral sclerosis (ALS). We analyzed retrospectively the effect of variation of …

[HTML][HTML] Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica

N Chihara, T Aranami, S Oki, T Matsuoka… - PloS one, 2013 - journals.plos.org
Neuromyelitis optica (NMO) is an inflammatory disease characterized by recurrent attacks of
optic neuritis and myelitis. It is generally accepted that autoantibodies against aquaporin 4 …

[HTML][HTML] CCR2+ CCR5+ T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis

W Sato, A Tomita, D Ichikawa, Y Lin… - The Journal of …, 2012 - journals.aai.org
Multiple sclerosis (MS) is a demyelinating disease of the CNS that is presumably mediated
by CD4+ autoimmune T cells. Although both Th1 and Th17 cells have the potential to cause …