Abstract Coronavirus disease 2019 (COVID-19) is causing disruptions in the global social
system. Japanese children and adolescents have had their schools closed, government …

ATP-binding cassette (ABC) transporters confer drug resistance against a wide range of
chemotherapeutic agents, including nucleoside and nucleotide based drugs. While …

The delivery of cancer chemotherapy to treat brain tumors remains a challenge, in part,
because of the inherent biological barrier, the blood–brain barrier. While its presence and …

The movement of anionic porphyrins (for example, haem) across intracellular membranes is
crucial to many biological processes, but their mitochondrial translocation and coordination …

Sphingosine kinase (SPHK) phosphorylates sphingosine to form a bioactive lipid mediator,
sphingosine 1-phosphate (S1P). S1P mediates such diverse biological processes as …

Abcb6 is a mammalian mitochondrial ATP-binding cassette (ABC) transporter that regulates
de novo porphyrin synthesis. In previous studies, haploinsufficient (Abcb6+/−) embryonic …

ABCG2 is a medically important ATP-binding cassette transporter with crucial roles in the
absorption and distribution of chemically-diverse toxins and drugs, reducing the cellular …

Hereditary porphyrias are caused by mutations in genes that encode haem biosynthetic
enzymes with resultant buildup of cytotoxic metabolic porphyrin intermediates. A long …

Controlling the activation of platelets is a key strategy to mitigate cardiovascular disease.
Previous studies have suggested that the ATP-binding cassette (ABC) transporter, ABCC4 …

The increased heme biosynthesis long observed in leukemia was previously of unknown
significance. Heme, synthesized from porphyrin precursors, plays a central role in oxygen …