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Tremor: a newly described adverse event with long-term itraconazole therapy
  1. Jodi M Lestner1,
  2. David W Denning1,2,3
  1. 1Department of Transitional Medicine, The University of Manchester, Manchester, UK
  2. 2Regional Mycology Laboratory, Manchester, UK
  3. 3Wythenshawe Hospital, Manchester, UK
  1. Correspondence to Miss Jodi M Lestner, The University of Manchester, Room 1.800, Stopford Building, Oxford Road, Manchester M13 9PT, UK; jodi.lestner{at}


Itraconazole is a widely prescribed triazole antifungal drug, often given for long periods. The authors report five cases of tremor related to itraconazole therapy, which occurred within 1–12 months of initiating treatment and resolved gradually following itraconazole withdrawal.

  • Itraconazole
  • side effect
  • tremor
  • microbiology
  • neuropharmacology
  • neurotoxicology
  • pharmacology

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  • Funding This study was funded by The Moulton Trust. The Fungal Research Trust supports the Regional Mycology Laboratory's culture collection.

  • Competing interests In the past 5 years, DWD has received grant support from Astellas, Merck, Pfizer, F2G, OrthoBiotech, Indevus, Basilea, the Fungal Research Trust, the Wellcome Trust, the Moulton Trust, The Medical Research Council, The National Institute for Health Research, The Chronic Granulomatous Disease Research Trust, the National Institute of Allergy and Infectious Diseases and the European Union. He has been an advisor/consultant to Basilea, Vicuron (now Pfizer), Pfizer, Schering Plough, Indevus, F2G, Nektar, Daiichi, Sigma Tau, Astellas, Gilead and York Pharma. He has been paid for talks on behalf of Schering, Astellas, Merck, GSK, Chiron, AstraZeneca and Pfizer. He holds founder shares in F2G Ltd and Myconostica Ltd, both University of Manchester spin-out companies.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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